Guide :

Triple Negative

My sister was diagnosed with invasive ductal carcinoma grade 3 stage 3 with lymph node involvement 9 out of 13 nodes positive for cancer. She is also triple negative.  This happened so fast less then 6 weeks.  She is going next week for pet scan to see if spread anywhere else.  The doctors told us that her stage 3 could be moved to stage 4 if this has spread any further.  Why is this cancer so aggressive?  She is 51 years old.  We are all very worried and scared.  What exactly does the triple negative mean?  Any he

Research, Knowledge and Information :


Triple Negative Breast Cancer - National Breast Cancer Foundation


Who is at risk for Triple Negative Breast Cancer? Triple negative breast cancer occurs in about 10-20% of diagnosed breast cancers and is more likely to affect ...
Read More At : www.nationalbreastcancer.org...

Triple Negative Breast Cancer Foundation - Official Site


Triple Negative Breast Cancer Foundation® is dedicated to supporting TNBC-specific research and providing meaningful programs/services to the TNBC community.
Read More At : tnbcfoundation.org...

Triple-negative breast cancer - Wikipedia


Triple-negative breast cancer (sometimes abbreviated TNBC) refers to any breast cancer that does not express the genes for estrogen receptor (ER), progesterone ...
Read More At : en.wikipedia.org...

Understanding Triple Negative Breast Cancer


These subtypes of breast cancer are generally diagnosed based upon the presence, or lack of, three “receptors” known to fuel most breast cancers: estrogen ...
Read More At : tnbcfoundation.org...

Triple-Negative Breast Cancer | Breastcancer.org


Testing negative for ER, PR, & HER2 indicates breast cancer is triple-negative. Learn more about triple-negative breast cancer now.
Read More At : www.breastcancer.org...

Triple Negative Breast Cancer | Susan G. Komen®


Learn all about triple negative breast cancer and who is likely to get TNBC. Also, discover treatment options.
Read More At : ww5.komen.org...

Triple-Negative Breast Cancer - WebMD


Triple-negative breast cancer is a rare type. It’s serious, but it responds well if you catch it early. WebMD has details on the causes, symptoms, and treatments.
Read More At : www.webmd.com...

Triple-Negative Breast Cancer – Treatment Options | CTCA


Get the facts about triple-negative breast cancer. Even though 10-20% of all breast cancers are triple-negative and there are a number of treatment options.
Read More At : www.cancercenter.com...

Triple Negative Breast Cancer Diagnosis & Treatment: Johns ...


The Johns Hopkins Breast Center in Baltimore, MD, has breast cancer specialists who are experienced with the diagnosis and treatment of triple negative breast cancer.
Read More At : www.hopkinsmedicine.org...

How Triple-Negative Breast Cancer Behaves and Looks


To understand triple-negative breast cancer, it’s important to understand receptors, which are proteins found inside and on the surface of cells.
Read More At : www.breastcancer.org...

Suggested Questions And Answer :


Triple Negative BC Info

Hi Laurie, I'm sorry you've gotten this diagnosis.  It really stinks.  I can hear the fear in your words.  I'm 46 and a mom -- I was 45 when I was diagnosed with bilateral BC, and the BC on my right side was triple negative.  It's become "popular" because Robin Roberts of Good Morning America was triple negative.  I also heard from my oncologist that it was both good and bad.  The one thing I heard was that while triple negative is more aggressive, it's also less likely to be a killer in the long run (i.e. beyond 5 years).  So, how do  you get to the point of getting to the five year mark?  Talk to your BC team.  What have you done so far?  What have they recommended for a treatment plan.  Are you being treated at a large medical center (preferably a research institution) where they focus on your breast cancer from a team perspective? Being diagnosed with triple negative is not a death sentence.  I'm certain of that.  I have some very stong advice for you -- don't go internet surfing for comforting answers.  I tried that one lonely day at the beginning of treatment and felt decidedly worse rather than better.  The internet can be a loose cannon kind of place.  The majority of sites that I found related to triple negative seemed to be addressing worst case scenarios, and testimonies from women that had gotten really bad news and were preparing for death.  I know that's out there, and if I ever experience a recurrence, believe me, I'll be visiting those sites for help and reassurance.  BUT, when you are newly diagnosed, that's not the place to go.  Get as much information from your drs. that you are clear on what you need to do to go on and live a long healthy life, then stop gathering more and more and more information.  It's too much food for negative thought.  This is just my opinion, having gone through this, but it's worked for me, and after a solid year of treatment, I'm to the other side with only reconstruction ahead of me when I choose.  And you know what Laurie?  I'm ok.  Really really ok.   Write to me privately if you want to talk more, ok? Warmly, Chris Healingwell62 Breast Cancer 1 & 2 Community Leader
Read More At : ...

Anyone else have Triple Negative Breast Cancer?

Hi, I googled "triple negative breast cancer  metaplastic", and came up with some very clear and helpful material.  There is one article http://www.nature.com/onc/journal/vaop/ncurrent/abs/1210014a.html that is very medical but explains it, that metaplastic is a rarer type of basal-like tumors.   Did the docs try to support your WBC with Neulastin, or something like that?  It sucks to have to get off a good tx because of #'s. There were lots of articles and other resources if you google like I did.  That's all I know. Good luck, my dear.
Read More At : ...

Triple Negative Breast Cancer Grade

I'm sending you a website that explains the Grading and Staging systems used. I don't know if the link will come thru "clickable" ... you may need to hand copy it and go from there.  There are so many factors it's best if you read it for yourself.   (http://www.cancerbackup.org.uk/Cancertype/Breast/Causesdiagnosis/Staginggrading)     Good Luck"
Read More At : ...

Triple negative=chemo?

I finished rads in 1/08  after 6 runs of AC-T. I had triple negative last June2007 and had lumpectomy with lymph node removal. I do know the Onc told me this was standard care for Triple Negative but your tumor is smaller than mine.There is a good web site just type in Triple Negative Breast cancer and you will see it as a forum.Triple Negative is suppose to be very responsive to chemo and it is a very aggressive cancer so you may want to be aggressive back.Good luck
Read More At : ...

Triple Negative Treatment Options

Hi, You are correct, there is no specific therapy for triple negative disease. Some of the research that is ongoing involves some similarities with triple negatives and BrCA-1 (a genetic predisposition to breast cancer). There is an investigational agent called PARP-1 inhibitors currently being evaluated in BrCA and may present an option also for 3-negatives. Another finding is that there seems to be an overexpression of EGFR (epidermal growth factor receptor - a structure on the tumor that normally requires signals to promote growth, but in cancer may be perpetually in an active growth promotion configuration), and there are several drugs that may target this: gefitinib, erlotinib, cetuximab, panitumumab. Another target worth pursuing is the tumor blood vessels there are drugs with this mechanism being targeted. There are still other drugs like mTOR (mammalian target of rapamycin) inhibitors out there. Some of these are in the stages where activity is still being measured so any broad recommendations cannot be made (but hey, we're only brainstorming afterall). On the practical side however, the best way to get additional treatment is in enrollment in a clinical trial. Discuss with your doctor if there is an ongoing trial in his/her insitution or if there are any nearby institutions where you can be enrolled. I don't know if it means anything to you, but your participation will help patients in the future in the same way that the research on patients who participated years ago have defined the treatment you already have received. Stay positive.
Read More At : ...

Triple Negative BC - Should I be tested for BRCA

     Should you be tested for the BRCA mutation?  Yes, probably.  This would give you and your oncologist some information with which to make an informed decision.  It would also give you information that would benefit your children and their need for extra vigilance in the future if you do have the mutation.      With regards to statistics...they are just statistical averages based on many, many cases of breast cancer.  Plus, most statistical data that you find on the internet is hopelessly out of date.  Statistics cannot predict what will happen to YOU.  Every person and every case of breast cancer is different.        The biggest problem with triple negative breast cancer is that there is no treatment beyond chemotherapy and radiation.  There is no herceptin, no tamoxifen, or any other drug that we can take for the next five years to help prevent a recurrence.  Although these drugs are beneficial, keep in mind that they are relatively recent in their development.  Most women ten or so years ago, only had chemotherapy and radiation available to them.  And, many of them are still around to tell their stories.  I have a co-worker who was treated for breast cancer over 25 years ago before all of these drugs were available. She has been fine all this time.      I, myself, was diagnosed with triple negative breast cancer in September of 2003.  I underwent a mastectomy and chemotherapy.  Since then, I have been fine and have not had a recurrence.  I, like you, had no lymph node involvement.        I don't know anything about your tumor...size, type, grade, stage...but if all of these are reasonable, your chances for survival are probably good.        I wish you luck and good health on your journey.
Read More At : ...

Triple Negative

hi jennifer i am also triple neg. i have been told it could be a good thing because you dont have to put those additional chmicals in body for 1 to 5 yrs. but i also may have new cancer near lungs so only time will tell. i did find a website called triple negative that is helpful. jay
Read More At : ...

triple-negative breast cancer treatment

Hi Mike, You asked about tx for TNBC, but the info you included stated "HER2-?". Did you later receive word that the HER2  was also neg.? (Otherwise it would not be triple neg. B C...) In any case, TNBC is treated much as the other types of BC (surgery, then possibly chemo and possibly radiation, as per the recommendations of the treatment team), with the exception that adjunctive tx with anti-hormals (such as tamoxifen) is not useful. Specific questions about the case you described would best be discussed with the oncologist and other members of the tx team, but please post again if there is anything else we can help you with. Best wishes...
Read More At : ...

Triple Negative

Hi Dawn, Triple Negative means that your BC is not responsive to estrogen, progesterone, and you are NOT HERS II + either.  That is why they call it Triple Negative cancer for what it ISN'T. My sister (a 26-year survivor of TNBC) is doing okay.  They did even have a name for her type back then.  She is also BRCA1+ (Google these things or Wiki them).  You'll get all the info you need.  Of course she caught it fairly early and treated quickly.  Has heart damage from the chemo (different back then), but she's still with us. I am also TNBC Thriver with metastatic.  Dx in Dec 2011.  I was clean for 8 months after chemo, surgery, rads, chemo 2nd time.  They did b/4 and after.  Anyway, now have lyphedema from completely axillary dissection.  Back in chemo in Jan of 2014.  Just finished Aug 5th!  PET on the 20th which I expect to be ROCKIN'.   I do a lot of supplements and green food WHILE on chemo.  I am not gonna die from the treatment.  No sir.  I personally believe it works BETTER, when you are healthier anyway.  So who knows what worked for the last PET.  All I know is it was GREAT and gave me lots of hope.  I had a local mets that took off, but was stable for some time.  I think I KNOW what caused the take off and it wasn't my refusing Arimadex anymore.  My TN is now 10% estrogen positive.  Go figure!  For me, I MUST feel that I am in charge and intuitively I KNOW what is happening in my body.  I listen to my body and MY cancer.  It is MY cancer.  I don't hate it or alienate myself from it.  It is part of ME, and that is okay.  The more okay it is, the less fear I have.  I talk to it logically, lovingly, and reasonably.  It listens too.  Gotta go for now.  Hope this helps.  God bless.
Read More At : ...

Triple negative breast cancer

These are all questions that you should be discussing with your oncologist, who has highly specialized training in regard to all these issues, and would have full access to all of the details of your case as well as your medical history, rather than with volunteers on  the Internet, don't you think?. One comment though: TNBC Grade 3 is a very aggressive type of cancer and should therefore receive very aggressive tx. I am providing a link to a research report dealing with this topic, as well as a brief quote from that report: --------------------------------------------------------------------------------------------------------------- http://www.sciencedaily.com/releases/2007/12/071216104305.htm Even Tiny Breast Tumors Can Be Aggressive And May Require Maximum Therapy ScienceDaily (Dec. 19, 2007) — Breast tumors that are 1 centimeter in size or smaller — no more than 0.4 inch in length — can still be very aggressive and may require more intensive therapy than is routinely offered today, say researchers at Mayo Clinic in Jacksonville, Fla. The study, which is being presented at the San Antonio Breast Cancer Symposium, is one of the few that has looked at outcomes of women who have tiny tumors that have not spread to the lymph nodes. The findings suggest that outcome of two types of breast cancer — those classified as HER2 positive (HER2+) and triple negative — may not depend on size alone. . Although only small numbers of women have the rarer cancer subtypes included in this study, the findings suggest that women with HER2+ and triple negative tumors should receive as much treatment as possible in order to prevent cancer relapse, Dr. Amar says. Researchers found that only 35 percent of women with triple negative cancer were treated with adjuvant chemotherapy (chemotherapy after surgery) despite the higher grade of the tumors. "Chemotherapy may not work as well as we would like in these tumors, but, still, physicians who treat patients with triple negative cancer should be aware of the higher risk of relapse, even if tumors are quite small," she says. ---------------------------------------------------------------------------------------------------------------------------- Best wishes....
Read More At : ...

Tips for a great answer:

- Provide details, support with references or personal experience .
- If you need clarification, ask it in the comment box .
- It's 100% free, no registration required.
next Question || Previos Question
  • Start your question with What, Why, How, When, etc. and end with a "?"
  • Be clear and specific
  • Use proper spelling and grammar
all rights reserved to the respective owners || www.online-medical-clinic.com || Terms of Use || Contact || Privacy Policy
Load time: 0.0563 seconds