Guide :

Triple negative breast cancer metastasized into Liver diagnosed in 2014.

To give you a background,patient is a female 60yrs age. She felt a lump in her left breast in Aug 2014, which the doctors confirmed after biopsy as triple negative. Further, the PET scan indicated that the cancer is also metastasized into Liver. Thereafter, as recommended by Doctors , she was give 6 cycles of Chemotherapy with drugs 'Docetaxel' and EPIRUBICIN, with doses after every 21 days. Thereafter, her PET scan done in Dec 14 indicated that the cancer is no longer active. This was followed by another PET in May 2015 with similar observation. Another PET was done in Nov 2015,

Research, Knowledge and Information :


Breast Cancer Topic: Stage IV...mets to liver...triple ...


A place for those managing the ups & downs of a Stage IV/metastatic breast cancer diagnosis. ... their triple negative breast cancer ... right into the liver.
Read More At : community.breastcancer.org...

Living with metastatic breast cancer (January 2014) | Susan G ...


Triple Negative Breast Cancer; ... For those living with metastatic breast cancer, ... In 2014, the Metastatic Breast Cancer Alliance will release a report to raise ...
Read More At : ww5.komen.org...

Metastatic Breast Cancer - National Breast Cancer Foundation


Triple Negative Breast Cancer ... Cancer cells penetrate into the circulatory or lymph system. ... She was diagnosed with metastatic breast cancer on April 27, ...
Read More At : www.nationalbreastcancer.org...

What’s the Prognosis for Stage 4 Breast Cancer? - Healthline


Wondering about your long-term outlook for stage 4 breast cancer? ... therapy for breast cancer. (2014 ... Treatment Options for Triple-Negative Breast Cancer ...
Read More At : www.healthline.com...

Triple-Negative Breast Cancer | Breastcancer.org


Testing negative for ER, PR, & HER2 indicates breast cancer is triple-negative. Learn more about triple-negative breast cancer now.
Read More At : www.breastcancer.org...

Metastatic Breast Cancer - Stage IV | Susan G. Komen®


Triple Negative Breast Cancer; ... liver or brain). ... they’ve lived at least 5 years since being diagnosed with metastatic breast cancer.
Read More At : ww5.komen.org...

Triple Negative Breast Cancer - National Breast Cancer Foundation


In March 2010, Penny was diagnosed with Stage 2B Triple-negative breast cancer. A busy salon owner, Penny realized that her diagnosis and treatment would completely ...
Read More At : www.nationalbreastcancer.org...

Triple Negative Breast Cancer Foundation - Official Site


Triple Negative Breast Cancer Foundation® is dedicated to supporting TNBC-specific research and providing meaningful programs/services to the TNBC community.
Read More At : tnbcfoundation.org...

Suggested Questions And Answer :


What are your thoughts on refusing Chemotherapy and Radiation treatments?

Hi, First some general information about the treatment of DCIS: The usual treatment is a lumpectomy to remove the affected area. This is often followed by radiation treatment, and/or  tamoxifen, if the DCIS is found to be hormone receptor positive.  On the other hand, some people believe DCIS is being overtreated, because it may never become invasive. The problem is, we don't have good ways to predict which ones will become invasive and which ones will not. Recent research has found that women with localized breast cancer are less likely to develop invasive cancer if they receive radiation after surgery. The researchers also found that treatment with the drug tamoxifen greatly reduced the risk of the recurrence of localized cancer. The study included patients with ductal carcinoma in situ (DCIS), the most common type of noninvasive breast cancer, who were followed for a median of 12.7 years. The researchers found that radiation after surgery reduced the risk of invasive cancer in the same breast by nearly 70 percent and decreased recurrent DCIS in the same breast by more than 60 percent. Radiation therapy had no effect on the other breast. "This study is very important in confirming the benefits of radiotherapy in the treatment of ductal carcinoma in situ and, most importantly, decreasing the incidence of invasive carcinoma developing in the same breast," said Dr. Lauren Cassell, chief of breast surgery at Lenox Hill Hospital in New York City. "If we could only identify which particular patients were most at risk, we could target our radiotherapy to those patients who truly benefit from it and avoid over-treating others." The study also found that treatment with tamoxifen lowered the risk of cancer recurrence in the same breast by about 30 percent, and it decreased the risk of new cancer in the other breast by more than 65 percent. In some cases where the DCIS is multifocal (in more that one location in the breast) or of a very aggressive type and  grade, some women will opt for more aggressive treatments, such as mastectomy and chemo. Regarding your specific case, I would imagine your doctors recommended both chemo and radiation because: 1. The size of your turmor was not small; 2. Triple negative breast cancer (TNBC) tends to be very aggressive (Do you know the grade of your tumor?) and  does not  have a targeted treament to lower the risk for recurrence (such as Tamoxifen  for hormone receptor positive BC); and 3. Women who develop invasive BC after being treated for DCIS have a higher mortality rate. My suggestion, before you refuse your doctors' recommendations, would be to at least get additional opinions from both a radiation oncologist and a medical oncologist outside of your medical group. If their  opinions are the same as those of your doctors, you might want to rethink your plan of only relying on "cancer-fighting foods." Best wishes, bluebutterfly
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triple-negative breast cancer treatment

Hi Mike, You asked about tx for TNBC, but the info you included stated "HER2-?". Did you later receive word that the HER2  was also neg.? (Otherwise it would not be triple neg. B C...) In any case, TNBC is treated much as the other types of BC (surgery, then possibly chemo and possibly radiation, as per the recommendations of the treatment team), with the exception that adjunctive tx with anti-hormals (such as tamoxifen) is not useful. Specific questions about the case you described would best be discussed with the oncologist and other members of the tx team, but please post again if there is anything else we can help you with. Best wishes...
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Breast Cancer spread in liver and bones

I'm going to answer your questions to the best of my ability but I would like to suggest that you post your concerns on the "Expert" Forum (Breast Cancer) where the Dr.s from The Cleveland Clinic answer. They may be offline for the Holiday week-end but they will get to you eventually.  Now to your questions ... #1 -- Your Oncologist would be the best source of information as far as treatment now BUT I do not believe that the metastises you mention can be erradicated ... only treated.  #2 -- This one would be best answered by the Oncologist also .... they know of any drugs available from various drug manufacturers that might be available at a reduced cost. It would depend greatly on the drug, the company, your circumstances (financial).  #3 -- Stage 4 (metastatic cancer) cannot be cured and therefore recurrance would not be a factor. Many pt. s with Stage 4 have survived a considerable length of time but this depends on the organs involved and the degree of involvement.   Kindest regards .....
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Triple negative breast cancer

These are all questions that you should be discussing with your oncologist, who has highly specialized training in regard to all these issues, and would have full access to all of the details of your case as well as your medical history, rather than with volunteers on  the Internet, don't you think?. One comment though: TNBC Grade 3 is a very aggressive type of cancer and should therefore receive very aggressive tx. I am providing a link to a research report dealing with this topic, as well as a brief quote from that report: --------------------------------------------------------------------------------------------------------------- http://www.sciencedaily.com/releases/2007/12/071216104305.htm Even Tiny Breast Tumors Can Be Aggressive And May Require Maximum Therapy ScienceDaily (Dec. 19, 2007) — Breast tumors that are 1 centimeter in size or smaller — no more than 0.4 inch in length — can still be very aggressive and may require more intensive therapy than is routinely offered today, say researchers at Mayo Clinic in Jacksonville, Fla. The study, which is being presented at the San Antonio Breast Cancer Symposium, is one of the few that has looked at outcomes of women who have tiny tumors that have not spread to the lymph nodes. The findings suggest that outcome of two types of breast cancer — those classified as HER2 positive (HER2+) and triple negative — may not depend on size alone. . Although only small numbers of women have the rarer cancer subtypes included in this study, the findings suggest that women with HER2+ and triple negative tumors should receive as much treatment as possible in order to prevent cancer relapse, Dr. Amar says. Researchers found that only 35 percent of women with triple negative cancer were treated with adjuvant chemotherapy (chemotherapy after surgery) despite the higher grade of the tumors. "Chemotherapy may not work as well as we would like in these tumors, but, still, physicians who treat patients with triple negative cancer should be aware of the higher risk of relapse, even if tumors are quite small," she says. ---------------------------------------------------------------------------------------------------------------------------- Best wishes....
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IIB Triple Negative Occult Cancer with CHF

Hi there. The H in TCH can very well mean Herceptin.  And I agree with you that this drug may not work on Her2Neu negative tumors.  The heart condition of your mother really makes things complicated since one of the most active drugs for breast cancer, adriamycin, has cardiotoxic effects.  I suggest you discuss this with her oncologist/doctors since Herceptin may not benefit her much (if her2neu negative), and her prognosis will be dependent on her stage of disease.  You can also inquire about the less cardiotoxic drugs such as epirubicin and the non-cardiotoxic drug methotrexate (though this drug is already outdated in breast cancer treatment). Regards and God bless.
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Triple Negative Breast Cancer

I'm sorry you're going through this with your friend. Triple negative cancers tend to be very aggressive cancers. Two things I would say .. She needs to get tested for a BRCA mutation and if it's found that she has it then she needs to be aggressive trying to get into a PARP inhibitor trial. Best wishes.
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Breast cancer now in liver and bones

If your Mother didn't have scans before or after her treatment last year then these areas of metastisis may have been developing. You state there were no signs of the cancer invading the lymphatic system; were lymph nodes removed at the time of her surgery? Mets to the bones is one of the easiest types to treat and women have survived for many years with this. The liver concern, if when biopsied proves to be cancerous, may require a different type of treatment. There is no way to offer a prognosis in your Mother's case since cancers respond differently to treatment. Stage 4 is Stage 4 no matter if there was previous treatment or not and it also depends on where the cancer has metastisized. Best wishes to both your Mother and you in this difficult time.
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What do I need to prepare for?

Hi, Breast cancer metastasis is seen most commonly to occur to the brain, bone and liver. The reports that you mention suggest that the breast cancer in your mother-in-law's case has spread to the liver and lungs. The lesions on CT are described as being metastatic most probably. The scan results are fairly accurate though not confirmatory. Also has a bone scan and CT or MRI head been done? That too would be required to assess the brain and bones for any metastatic lesions. In such cases of advanced cancer the management plan is usually palliative as opposed to curative treatment. Discuss the details with her doctor and you would be helping her emotionall by being there for her appointments with the doctor. Goodluck.
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Bi-Rads 3 Classification

Mastectomy sounds a bit drastic .... the 6 month follow-up demonstrates that you are receiving good medical care. It would be strictly a personal decision but finding a Surgeon to agree to a mastectomy might be a problem.
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